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Research Scientist, DEL Chemistry

Company: Arvinas Inc.
Location: New Haven
Posted on: May 14, 2022

Job Description:

Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas' PROTAC - Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas' pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer. is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company's values and purpose - to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It's an exciting time to be in drug development and it's an exciting time to be at Arvinas. But don't just take our word for it - here's what Arvinas employees are saying . For more information, please visit . Position Summary An opportunity to work in a multidisciplinary team environment to design, synthesize, and screen DNA Encoded Libraries that incorporate our deep knowledge around key PROTAC - elements. Developing unique chemistries, testing, and validating reagents, carrying out DNA ligation steps, and completing the full Encoded Libraries are central to the position. We are seeking a highly motivated individual who can bring a constellation of skills to bear on expanding our uniquely tailored collection of DELs. This individual will also be responsible for reaction analysis, library QC, data recording and reporting throughout the process. This creative scientist will be an essential part of helping us streamline our library production workflow and grow our capabilities. Level will be determined by relevant experience. This position will be located at our headquarters in New Haven, CT. Principal Responsibilities Key responsibilities of this role include, but are not limited to:

  • Synthesis, purification, and characterization of proprietary DNA Encoded Libraries
  • Application of synthetic chemistry knowledge to evaluate reactions and reagents for on-DNA, aqueous synthesis
  • Apply plate-based parallel synthesis strategies in a split-and-pool manner
  • Apply automated synthesis skills using Tecan liquid handler to make DELs.
  • Analyze, interpret, and report experimental results at chemistry and program meetings.
  • Deposit and maintain library building block and DNA sequence record in database
  • Maintain detailed records of experiments in electronic lab
  • Contribute to conceptions, presentations, publications, and patents
  • Maintain a knowledge of literature related to areas of research Qualifications
    • Direct experience with DNA encoded library techniques is a strong plus
    • Parallel synthesis/combinatorial chemistry experience is a plus
    • Hands on experience with automation and liquid handler (TECAN) techniques is a plus
    • Strong knowledge of traditional and contemporary synthetic chemistry and/or bioconjugate chemistry
    • Excellent verbal and written communication skills with the ability and desire to collaborate across functional teams
    • Maintains orderly and timely record of experiments and results, including SOPs and protocols
    • Maintains accountability for ensuring own goals and those of the team are achieved
    • Contributes to professional/technical reports and writes scientific articles, publications and patents as required
    • Maintains safe working environment for self and others
    • Ability to summarize and transparently present work status in group settings
    • A successful candidate will bring an enabling attitude, be a problem solver and have a desire to work in a collaborative manner with peers and pan-disciplinary colleagues in a project setting Education
      • Ph.D. or BS/MS synthetic chemist with 8+ years of pharma/biotech-based experience Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit Arvinas is an Equal Opportunity employer

Keywords: Arvinas Inc., New Haven , Research Scientist, DEL Chemistry, Other , New Haven, Connecticut

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