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Senior Director, Small Molecule Research

Company: Alexion Pharmaceuticals, Inc.
Location: New Haven
Posted on: June 12, 2021

Job Description:

  • This position is Essential based in New Haven, CT with the expectation of being onsite on a regular basis*

Position Summary

The role & responsibilities of the Senior Director/ Medicinal Chemistry will combine scientific decision-making and organizational leadership to advance small molecule drug discovery campaigns from hit identification through development candidate.

Principal Responsibilities

  • Leads and supervises a group of research scientists / associates
  • Fosters a climate of creativity, but also leads by example by bringing forth ideas to the group. Encourages others, facilitates brainstorming
  • Connects with staff members to motivate and coach and takes responsibility for staff development. Ensures appropriate level of training. Complies with all requirements of the Alexion performance management process. Provides justification for new staff and participates in hiring.
  • Establishes and manages consistent work processes for planning, evaluating progress, problem solving and prioritizing, aimed at timely, high quality scientific deliverables
  • Effectively networks within Research & Development to understand priorities and allocates effort amongst programs that aligns with these priorities
  • Ensures that the team complies with all company and departmental polices around notebook, scientific reports, QA initiatives and safety, as well as any associated mandatory training.

  • Oversees medicinal chemistry efforts in advancing small molecule discovery programs
  • Leads multidisciplinary small molecule drug discovery project teams in a fast-paced, results-driven environment
  • Design, implement and execute medicinal chemistry strategies
  • Plan and execute on resource allocation to achieve project goals
  • Provide strategic, scientific, and managerial leadership in a combination of internal and outsourced medicinal chemistry environment
  • Collaborate effectively with the leadership team and other departments and functions
  • Contribute to the overall scientific strategy and success of ALXN pipelines

  • Participates in BD diligence activities
  • Serves as an in-house expert in small molecule drug discovery and takes lead in the evaluation of in-licensing opportunities
  • Evaluates and make recommendations with respect to external research proposals regrading small molecule discovery/development candidates


  • Doctoral degree (Ph.D.) or equivalent in Synthetic Organic Chemistry or Medicinal Chemistry 10+ years of drug discovery experience in the biotech/pharmaceutical industry, with a strong track record of scientific innovation and success in delivering clinical candidates
  • Broad background in all aspects of drug discovery, with working knowledge of ADME/PK, target coverage, pharmacology, physicochemical property-driven optimization and computational chemistry
  • A record of success in partnering with and leveraging computational chemistry for structure-based and property-based drug design of clinical candidates
  • Significant experience in leading synthetic chemistry CRO activities
  • A leader with strong organizational, interpersonal, communication and managerial expertise who motivates and inspires others to achieve corporate scientific objectives


  • Doctoral degree (Ph.D.) or equivalent in Synthetic Organic Chemistry or Medicinal Chemistry
  • LIDI-1
  • #LI-Remote

Some opportunities happen only once in a lifetime - like a job where you have the extraordinary opportunity to change lives. At Alexion, such opportunities arise through our unwavering mission to serve patients and families affected by rare diseases. These patients are our guiding star, and we act with integrity, urgency, and discipline because we know their lives are at stake.

Alexion is a global biopharmaceutical company focused on serving patients and families affected by rare diseases and devastating conditions through the discovery, development and commercialization of life-changing medicines. As a leader in rare diseases for more than 25 years, Alexion has developed and commercializes two approved complement inhibitors to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS), as well as the first and only approved complement inhibitor to treat anti-acetylcholine receptor (AchR) antibody-positive generalized myasthenia gravis (gMG) and neuromyelitis optica spectrum disorder (NMOSD). Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D) as well as the first and only approved Factor Xa inhibitor reversal agent. In addition, the company is developing several mid-to-late-stage therapies, including a copper-binding agent for Wilson disease, an anti-neonatal Fc receptor (FcRn) antibody for rare Immunoglobulin G (IgG)-mediated diseases and an oral Factor D inhibitor as well as several early-stage therapies, including one for light chain (AL) amyloidosis, a second oral Factor D inhibitor and a third complement inhibitor. Alexion focuses its research efforts on novel molecules and targets in the complement cascade and its development efforts on the core therapeutic areas of hematology, nephrology, neurology, metabolic disorders and cardiology. Headquartered in Boston, Massachusetts, Alexion has offices around the globe and serves patients in more than 50 countries. Further information about Alexion can be found at:

As a leading employer in our industry, Alexion is proud to offer a highly competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more.

Keywords: Alexion Pharmaceuticals, Inc., New Haven , Senior Director, Small Molecule Research, Other , New Haven, Connecticut

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